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Coordinating multidisciplinary care in severe hypertriglyceridemia (sHTG) is essential, from assessing triglyceride thresholds and recognizing the clinical signs to addressing disease burden, differentiating sHTG vs familial chylomicronemia syndrome (FCS), and knowing when to prioritize acute pancreatitis prevention. Use these slides to understand the latest guidance on providing personalized sHTG and FCS care that aligns with guideline-directed algorithms when using foundational therapy and emerging ApoC-III–targeted agents.